The 20 most successful fast food chains in America released its annual QSR 50 report of the top brands in the quick service and fast casual industries. . 3. Subway. Flickr/stargamesspielernamevergessen.win U.S. systemwide sales: $ billion. Many of the biggest American fast - food brands are available all over the world today. Which familiar chains have the most international units? Here are the top. Top 10 American Fast Food Chains We update DAILY with 2- 3 Top 10 lists, Origins, Biographies, Versus.